锟絕去十锟斤拷見锟紺锟剿干硷拷锟斤拷锟斤拷锟紸锟斤拷锟斤拷W锟斤拷锟絉锟斤拷锟紻锟斤拷锟叫撅拷锟斤拷锟絯锟劫發(f锟斤拷)展锟斤拷锟缴硷拷锟斤拷锟斤拷锟絰锟斤拷锟街伙拷锟酵硷拷锟斤拷锟斤拷锟缴硷拷锟斤拷锟斤拷锟斤拷锟斤拷 锟斤拷锟杰維锟街和凤拷(w锟斤拷n)锟斤拷锟経锟斤拷锟斤拷锟絞锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟絉锟斤拷試锟斤拷锟斤拷涌锟紽(xi锟斤拷n)锟斤拷探锟斤拷锟缴硷拷锟斤拷锟斤拷锟斤拷锟斤拷锟睫忥拷锟斤拷锟斤拷锟絀锟斤拷锟较碉拷y(t锟斤拷ng)锟斤拷锟斤拷锟斤拷 锟絎锟斤拷锟斤拷規(gu锟斤拷)锟斤拷锟斤拷锟酵標準伙拷锟斤拷锟皆硷拷锟斤拷全锟斤拷效锟斤拷锟斤拷路锟斤拷锟侥癸拷锟絉锟斤拷锟窖具傦拷锟斤拷锟斤拷锟侥科學锟斤拷論锟酵岋拷锟絗锟斤拷锟紸锟斤拷锟斤拷锟斤拷锟絉锟斤拷請锟斤拷锟斤拷锟斤拷杉锟斤拷锟斤拷锟斤拷A锟叫撅拷锟斤拷一锟斤拷锟斤拷锟揭猴拷锟斤拷锟斤拷锟睫忥拷锟斤拷锟斤拷锟斤拷锟斤拷I锟斤拷杉锟斤拷锟斤拷芯锟斤拷锟角帮拷锟斤拷R锟斤拷锟叫撅拷锟斤拷锟揭癸拷同撰锟斤拷锟斤拷锟絖锟缴碉拷每锟斤拷锟斤拷锟斤拷锟斤拷锟絔锟斤拷锟斤拷锟斤拷锟斤拷3位锟斤拷锟絇锟絀锟斤拷膶锟斤拷铱锟斤拷Y锟斤拷锟斤拷锟斤拷目前锟缴硷拷锟斤拷锟絀锟斤拷锟叫撅拷锟斤拷锟斤拷锟斤拷锟斤拷锟絪锟斤拷锟斤拷锟斤拷锟絉锟斤拷锟斤拷锟杰斤拷Q锟斤拷锟叫碉拷锟缴伙拷锟斤拷旨锟节滐拷通锟斤拷锟斤拷锟斤拷覈锟斤拷锟斤拷锟斤拷迯锟斤拷锟斤拷锟斤拷I锟斤拷锟斤拷赂杉锟斤拷锟斤拷锟斤拷A锟斤拷锟絉锟斤拷锟叫撅拷锟斤拷锟斤拷锟竭碉拷锟絁知锟斤拷锟斤拷锟节革拷锟矫碉拷锟狡動干硷拷锟斤拷锟斤拷锟絉锟斤拷锟紻锟斤拷锟斤拷锟斤拷锟叫撅拷锟斤拷希锟斤拷锟斤拷锟斤拷锟絉锟侥發(f锟斤拷)锟斤拷锟斤拷锟杰夠激發(f锟斤拷)該锟絀锟斤拷未锟斤拷锟侥革拷锟絴锟斤拷锟叫撅拷去锟斤拷探锟斤拷锟酵斤拷Q锟节憋拷锟斤拷锟絉锟斤拷未锟斤拷Q锟斤拷锟斤拷锟絇锟斤拷锟絵锟斤拷
1 锟斤拷锟絫
锟斤拷锟斤拷锟絉锟斤拷指锟缴硷拷锟斤拷锟斤拷一锟酵拷r锟竭傦拷锟斤拷锟揭革拷锟斤拷锟斤拷锟斤拷锟酵分伙拷锟斤拷锟杰的硷拷锟斤拷锟斤拷锟斤拷锟皆侊拷锟斤拷锟斤拷胎锟組锟斤拷锟斤拷也锟斤拷锟皆侊拷锟皆筹拷锟絯锟組锟斤拷锟斤拷锟斤拷锟絯锟斤拷锟竭拷锟絯锟斤拷锟絯锟斤拷锟斤拷x锟斤拷锟斤拷锟斤拷锟斤拷s锟斤拷锟斤拷锟紹(y锟斤拷ng)锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟角诧拷锟斤拷锟紹(y锟斤拷ng)锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟絩锟斤拷锟竭冿拷锟斤拷锟斤拷
1.1锟絖展锟缴硷拷锟斤拷锟絉锟斤拷前锟叫撅拷锟斤拷锟絉锟斤拷锟叫撅拷锟斤拷要锟斤拷
2015 锟斤拷锟斤拷锟斤拷锟斤拷锟絣(w锟斤拷i)锟斤拷锟斤拷計锟斤拷锟斤拷锟斤拷委锟絋锟斤拷锟斤拷锟紽(xi锟斤拷n)锟斤拷锟斤拷锟絣(w锟斤拷i)锟斤拷锟斤拷锟斤拷委锟絋锟斤拷锟斤拷锟酵囷拷锟斤拷食品藥品锟絆(ji锟斤拷n)锟斤拷锟斤拷锟斤拷锟斤拷锟街ｏ拷锟紽(xi锟斤拷n)锟斤拷锟斤拷 藥品锟絆(ji锟斤拷n)锟斤拷锟斤拷锟斤拷锟街ｏ拷锟紹锟絤(x锟斤拷)锟絣(f锟斤拷)锟斤拷锟斤拷锟缴硷拷锟斤拷锟絉锟斤拷锟叫撅拷锟斤拷锟斤拷锟絢锟斤拷锟斤拷試锟叫ｏ拷锟斤拷[1]锟斤拷锟斤拷锟缴硷拷锟斤拷锟狡勶拷锟絴锟斤拷锟斤拷锟狡硷拷锟絉锟斤拷前锟叫撅拷指锟斤拷 原锟絫锟斤拷試锟叫ｏ拷锟斤拷[2]锟酵★拷锟絇锟斤拷锟絖展锟缴硷拷锟斤拷锟絉锟斤拷锟叫撅拷锟紺锟斤拷锟戒案锟斤拷锟斤拷锟斤拷通知锟斤拷[3]锟斤拷锟斤拷锟斤拷锟�锟斤拷锟斤拷志锟斤拷锟缴硷拷锟斤拷锟紻锟斤拷锟絉锟斤拷锟叫撅拷 锟斤拷锟斤拷锟絇锟斤拷锟斤拷锟斤拷亍锟斤拷杉锟斤拷锟斤拷R锟斤拷前锟叫撅拷锟斤拷锟絉锟斤拷锟叫撅拷要锟斤拷锟斤拷循锟紷锟斤拷锟斤拷锟斤拷叩锟皆拷t指锟斤拷锟斤拷锟組锟斤拷锟斤拷
1.1.1 锟缴硷拷锟斤拷锟絉锟斤拷前锟叫撅拷要锟斤拷
锟斤拷須囷拷謹锟絆計锟叫撅拷計锟斤拷锟斤拷記錄堬拷锟斤拷锟斤拷鑼嶏拷锟阶凤拷锟�锟斤拷锟絖锟斤拷試锟斤拷锟较科學锟斤拷锟絫(y锟斤拷) 锟絎锟斤拷要锟襟，烇拷杉锟斤拷锟斤拷R锟斤拷試锟斤拷芯锟斤拷峁╋拷锟巾毦邆锟侥筹拷挚茖W锟斤拷锟斤拷(j锟斤拷)锟斤拷锟斤拷锟矫硷拷锟斤拷要锟斤拷锟絚锟絉锟斤拷锟斤拷锟斤拷一锟斤拷锟斤拷锟斤拷锟斤拷锟絘品 锟斤拷锟斤拷锟絘锟酵加癸拷锟斤拷锟斤拷跐M锟斤拷藥品锟斤拷锟絘锟絴锟斤拷锟斤拷锟斤拷規(gu锟斤拷)锟斤拷锟斤拷good manufacture practices, GMP锟斤拷锟侥環(hu锟斤拷n)锟斤拷锟斤拷锟組锟斤拷锟斤拷锟斤拷锟解，還 锟斤拷要锟斤拷锟斤拷锟斤拷群锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷M锟斤拷(w锟斤拷n)锟斤拷锟斤拷锟斤拷锟斤拷 / 锟斤拷 / 锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟街伙拷锟斤拷锟斤拷锟斤拷W锟斤拷锟杰猴拷效锟斤拷锟組锟叫凤拷锟斤拷锟絙锟斤拷锟斤拷锟斤拷锟斤拷模锟斤拷 锟斤拷锟絰锟斤拷锟斤拷循锟絧锟劫ｏ拷reduce锟斤拷锟斤拷锟斤拷(y锟斤拷u)锟斤拷锟斤拷refine锟斤拷锟酵达拷锟芥（replace锟斤拷锟斤拷锟斤拷原锟絫锟斤拷锟斤拷效锟斤拷锟叫撅拷锟絆計原锟絫要锟斤拷模锟組锟絉锟斤拷試锟� 锟絣锟斤拷锟斤拷锟斤拷锟侥統(t锟斤拷ng)計锟斤拷效锟斤拷锟斤拷锟絤锟斤拷锟侥岋拷锟秸★拷锟絊锟紺锟斤拷锟斤拷盲锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷效锟斤拷锟絇系锟斤拷锟斤拷锟斤拷全锟斤拷锟叫撅拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟� 锟斤拷锟斤拷锟斤拷位锟斤拷锟斤拷锟街诧拷锟絚锟街伙拷锟斤拷锟斤拷锟斤拷锟斤拷锟絃锟斤拷锟节的匡拷锟杰讹拷锟斤拷锟斤拷锟矫的監(ji锟斤拷n)锟統锟斤拷
1.1.2 锟缴硷拷锟斤拷锟絉锟斤拷锟叫撅拷锟斤拷要锟斤拷 锟缴硷拷锟斤拷锟絉锟斤拷锟叫撅拷锟紺锟斤拷锟斤拷锟斤拷蠂锟斤拷锟揭拷锟�锟斤拷锟缴硷拷锟斤拷锟絉锟斤拷锟叫撅拷锟侥匡拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷 锟戒案锟侥機锟斤拷锟斤拷施锟斤拷锟缴硷拷锟斤拷锟絉锟斤拷锟叫撅拷锟斤拷須具傦拷锟街的科學锟斤拷锟斤拷(j锟斤拷)锟斤拷锟斤拷锟斤拷锟斤拷锟皆囷拷吆凸锟斤拷锟斤拷锟斤拷锟斤拷A锟节碉拷锟斤拷锟芥及锟絃锟経锟斤拷 锟紸锟节碉拷锟斤拷锟芥應锟斤拷锟絕锟斤拷锟杰筹拷锟紽(xi锟斤拷n)锟侥損锟斤拷锟斤拷锟絉锟斤拷锟叫撅拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟铰版《藥锟斤拷锟絉锟斤拷試锟斤拷|锟斤拷锟斤拷锟斤拷規(gu锟斤拷)锟斤拷锟斤拷[4]锟斤拷要锟襟，革拷 锟斤拷锟斤拷锟狡勶拷锟斤拷锟较★拷锟缴硷拷锟斤拷锟狡勶拷锟絴锟斤拷锟斤拷锟狡硷拷锟絉锟斤拷前锟叫撅拷指锟斤拷原锟絫锟斤拷試锟叫ｏ拷锟斤拷[2]锟斤拷要锟斤拷锟斤拷同锟絩通锟絕锟紺锟斤拷锟侥傦拷锟巾審锟斤拷锟� 锟絎锟絞锟斤拷锟介并锟结交锟斤拷锟斤拷锟絣(w锟斤拷i) 锟斤拷锟斤拷锟斤拷委锟絋锟斤拷锟酵囷拷锟斤拷藥品锟絆(ji锟斤拷n)锟斤拷锟斤拷锟斤拷锟街備案锟斤拷锟叫撅拷锟結锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷試锟斤拷锟組锟斤拷锟絃锟斤拷锟絊锟絃锟絆(ji锟斤拷n)锟統锟斤拷锟絬锟絩锟缴硷拷锟斤拷锟絉锟斤拷锟叫撅拷锟斤拷锟絃锟节帮拷全锟皆猴拷锟斤拷效锟皆★拷
1.2 锟缴硷拷锟斤拷锟斤拷锟斤拷锟斤拷锟絇锟絘品锟狡傦拷C锟斤拷锟斤拷要锟斤拷
锟脚干硷拷锟斤拷锟斤拷锟斤拷锟斤拷锟絇锟絘品锟狡傦拷C锟斤拷锟斤拷锟斤拷锟铰猴拷锟絈锟紺锟斤拷锟斤拷锟斤拷锟絆锟斤拷锟叫凤拷锟较標準碉拷 GMP 锟斤拷锟絘車锟絞锟斤拷锟斤拷锟絯锟絝锟斤拷锟斤拷锟街诧拷 锟劫硷拷锟斤拷锟斤拷锟斤拷 YY0033 锟斤拷锟斤拷锟斤拷t(y锟斤拷)锟斤拷锟斤拷械锟斤拷锟絘锟剿滐拷锟斤拷锟斤拷锟街凤拷锟斤拷藥品 GMP 要锟斤拷锟斤拷每锟絖锟絰锟斤拷锟斤拷使锟矫讹拷锟斤拷锟斤拷锟斤拷锟侥標準诧拷 锟斤拷锟斤拷锟教ｏ拷standard operation procedure, SOP锟斤拷锟斤拷
锟狡機锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷 GMP 要锟斤拷锟斤拷锟斤拷锟斤拷锟侥干硷拷锟斤拷锟狡勶拷锟狡傦拷锟絴锟斤拷锟斤拷锟斤拷 锟絯系锟斤拷锟斤拷锟絆锟斤拷锟斤拷锟斤拷锟斤拷锟絴锟斤拷锟斤拷锟斤拷锟斤拷锟絋锟斤拷锟斤拷锟斤拷锟絴锟斤拷锟斤拷锟紺锟斤拷锟絴锟斤拷锟斤拷锟狡碉拷職責锟斤拷锟紺锟斤拷锟斤拷锟斤拷锟斤拷(j锟斤拷)每锟絅锟缴硷拷锟斤拷锟狡勶拷锟斤拷锟斤拷锟皆硷拷 锟斤拷锟狡備工藝锟組锟斤拷锟絃锟経锟絬锟斤拷锟斤拷
锟角機锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟絴锟斤拷锟斤拷锟斤拷锟斤拷锟皆ｏ拷指锟斤拷锟斤拷锟絯锟侥干硷拷锟斤拷锟狡勶拷锟狡傦拷锟斤拷锟截撠燂拷锟�锟斤拷锟絴 锟斤拷锟斤拷锟斤拷負責锟剿猴拷锟絴锟斤拷锟节欙拷锟斤拷锟斤拷同锟絩锟斤拷锟斤拷锟剿員锟斤拷锟絆锟斤拷锟斤拷锟絥锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟絇锟剿員锟斤拷蓪锟斤拷I(y锟斤拷)知锟絉锟斤拷锟斤拷全锟斤拷锟給锟斤拷锟斤拷锟斤拷锟紸 锟斤拷锟斤拷锟斤拷訓锟斤拷锟絕锟絤(x锟斤拷)锟斤拷锟斤拷锟斤拷锟斤拷锟絆锟斤拷锟組锟斤拷計锟斤拷锟斤拷校锟酵維锟給锟斤拷锟絖锟斤拷锟狡勶拷锟斤拷锟絘锟侥準確锟皆★拷
2 锟斤拷锟斤拷锟斤拷锟睫忥拷锟斤拷锟斤拷锟絀锟斤拷锟斤拷锟叫撅拷锟斤拷見锟侥干硷拷锟斤拷锟斤拷锟�
2.1 锟斤拷锟斤拷锟絞锟斤拷锟絴锟缴硷拷锟斤拷 锟斤拷锟斤拷锟絞锟斤拷锟絴锟缴硷拷锟斤拷锟斤拷bone marrow mesenchymal stem cells, BMMSCs锟斤拷锟角從癸拷锟斤拷M锟斤拷锟叫凤拷锟絰锟紷取锟斤拷一锟斤拷g锟斤拷 锟絴锟缴硷拷锟斤拷锟斤拷F(xi锟斤拷n)riedenstein 锟斤拷[5]锟斤拷 1976 锟斤拷锟阶次堬拷锟�锟斤拷BMMSCs 锟斤拷锟絅锟斤拷锟斤拷锟絃锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟竭層組锟斤拷锟斤拷锟斤拷锟街伙拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷 锟斤拷锟斤拷锟叫碉拷锟斤拷血锟斤拷锟斤拷锟斤拷锟斤拷锟街撅拷铮–D34锟斤拷CD14锟斤拷CD45 锟饺ｏ拷锟斤拷 BMMSCs 锟叫筹拷锟斤拷员锟斤拷_[6- 7]锟斤拷BMMSCs 锟斤拷锟斤拷锟斤拷_锟侥橈拷 記锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷兀锟紺D49锟斤拷CD29锟斤拷LFA- 3锟斤拷锟斤拷锟斤拷锟斤拷锟津蛋白筹拷锟斤拷锟藉（CD54锟斤拷CD102锟斤拷锟斤拷血锟杰硷拷锟斤拷黏附锟斤拷锟接ｏ拷CD106锟斤拷 CD44锟斤拷CD166锟斤拷锟斤拷[8- 10]锟斤拷BMMSCs 锟斤拷要锟斤拷源锟节癸拷锟斤拷液锟斤拷锟斤拷通锟絕锟斤拷前锟较硷拷锟斤拷锟教筹拷取锟斤拷也锟斤拷锟斤拷脛锟斤拷锟斤拷锟缴癸拷锟斤拷锟截骨等癸拷锟斤拷 锟紷取锟斤拷锟斤拷取锟侥癸拷锟斤拷液通锟絕锟杰讹拷锟捷讹拷锟絰锟侥凤拷锟斤拷全锟斤拷锟斤拷锟斤拷锟紹(y锟斤拷ng)锟絅锟节篩锟絰锟斤拷锟斤拷锟斤拷式锟斤拷锟斤拷锟絰锟斤拷锟絰锟斤拷锟斤拷锟斤拷锟竭达拷锟介法锟饺可篩锟絰 锟斤拷锟斤拷小锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟絕锟竭碉拷 BMMSCs[11]锟斤拷BMMSCs 锟侥擴锟斤拷锟劫度極锟斤拷锟斤拷锟教時锟絞锟斤拷锟斤拷锟紹(y锟斤拷ng)锟襟即可獲取锟斤拷锟斤拷锟侥硷拷锟斤拷锟斤拷
2.2 脂锟斤拷锟斤拷源锟缴硷拷锟斤拷 1973 锟斤拷锟斤拷Poznanski 锟斤拷锟斤拷脂锟斤拷锟叫發(f锟斤拷)锟紽(xi锟斤拷n)锟斤拷锟斤拷锟斤拷诔锟斤拷w锟絊锟接的硷拷锟斤拷锟斤拷锟斤拷锟絯锟斤拷也锟杰憋拷锟街达拷锟絰锟斤拷锟斤拷[12]锟斤拷2001 锟斤拷锟斤拷 Zuk 锟斤拷锟紺锟斤拷锟紷些锟斤拷锟斤拷锟叫达拷锟斤拷锟絞锟斤拷锟絴锟缴硷拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷脂锟斤拷锟斤拷源锟缴硷拷锟斤拷锟斤拷adipose- derived stem cells锟斤拷ADSCs锟斤拷[13]锟斤拷锟斤拷锟斤拷_锟斤拷锟絴锟斤拷锟斤拷锟斤拷锟絇锟斤拷志锟斤（CD29锟斤拷CD44锟斤拷锟斤拷锟絞锟斤拷锟絴锟斤拷锟斤拷锟斤拷志锟斤（CD73锟斤拷CD90锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟絖锟斤拷血源锟皆硷拷锟斤拷锟斤拷 志锟斤拷 CD45 锟斤拷 MHC锟斤拷锟斤拷锟絇锟斤拷锟斤拷 HLA- DR[13- 14]锟斤拷锟斤拷脂锟斤拷锟組锟斤拷锟叫凤拷锟絰 ADSCs 锟斤拷锟斤拷要锟斤拷锟斤拷锟斤拷锟絲原酶锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷 锟斤拷锟斤拷锟斤拷锟絘锟斤拷锟絕锟竭ｏ拷锟斤拷锟斤拷還锟叫組锟斤拷锟終锟絅锟节凤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷直锟斤拷锟絰锟侥凤拷锟斤拷锟紺械锟斤拷蕩锟斤拷锟斤拷锟斤拷锟斤拷效锟斤拷锟絕锟斤拷[15- 17]锟斤拷锟斤拷锟斤拷锟絲原 酶處锟斤拷脂锟斤拷锟組锟斤拷锟斤拷锟斤拷锟秸硷拷锟侥底層硷拷锟斤拷锟紽锟斤拷锟絈锟斤拷脂锟斤拷血锟杰伙拷锟絴片锟轿ｏ拷stromal vascular fraction锟斤拷SVF锟斤拷锟斤拷锟斤拷一類帮拷锟斤拷 ADSCs锟斤拷脂锟斤拷前锟絯锟斤拷锟斤拷锟斤拷脂锟斤拷锟芥細锟斤拷锟斤拷锟斤拷锟杰硷拷锟斤拷锟斤拷锟斤拷皮锟斤拷锟斤拷锟斤拷锟斤拷皮锟芥細锟斤拷锟斤拷锟轿猴拷 / 锟斤拷锟缴硷拷锟斤拷锟斤拷锟斤拷血锟缴硷拷锟斤拷锟斤拷锟节冿拷 锟侥拷锟絴锟皆硷拷锟斤拷群锟斤拷也锟斤拷锟叫达拷锟組锟組锟斤拷锟斤拷锟斤拷锟侥癸拷锟斤拷[18- 19]锟斤拷
2.3 臍锟斤拷锟絞锟斤拷锟絴锟缴硷拷锟斤拷 臍锟斤拷锟絞锟斤拷锟絴锟缴硷拷锟斤拷锟斤拷umbilical cord mesenchymal stem cells, UCMSCs锟斤拷锟斤拷一锟絅锟斤拷臍锟斤拷锟斤拷锟絰锟斤拷锟絞锟斤拷锟絴锟缴硷拷锟斤拷锟斤拷 锟斤拷锟斤拷锟斤拷 21 锟斤拷锟給锟斤拷锟斤拷锟斤拷锟絒20]锟斤拷臍锟給锟絵锟斤拷皮锟斤拷臍锟斤拷 Wharton's 锟絲锟絴锟斤拷血锟斤拷锟杰囷拷锟組锟斤拷锟叫撅拷锟缴凤拷锟絰锟紷锟斤拷 UCMSCs[21- 23]锟斤拷UCMSCs 锟斤拷锟叫碉拷锟酵碉拷锟絞锟斤拷锟絴锟缴硷拷锟斤拷锟斤拷锟斤拷锟街撅拷锟斤拷锟絖锟斤拷锟絚锟斤拷CD29锟斤拷CD44锟斤拷CD105锟斤拷CD166锟斤拷OCT- 4 锟斤拷 c- myc 锟斤拷锟斤拷 锟斤拷员锟斤拷_,CD34 锟斤拷 CD14 锟斤拷锟斤拷锟斤拷员锟斤拷_[24]锟斤拷UCMSCs 锟斤拷锟斤拷锟絃锟斤拷锟斤拷锟揭革拷锟铰★拷锟竭擴锟斤拷锟皆和憋拷锟酵凤拷(w锟斤拷n)锟斤拷锟斤拷[25]锟斤拷目前锟叫無 锟斤拷锟絁锟侥凤拷锟絰 UCMSCs 锟斤拷锟斤拷锟斤拷使锟斤拷锟絕锟斤拷姆锟斤拷锟斤拷薪M锟斤拷锟終锟絅锟节凤拷锟斤拷酶锟斤拷锟斤拷锟斤拷锟斤拷UCMSCs 锟侥侊拷源锟斤拷锟絫(y锟斤拷)锟斤拷锟経锟斤拷锟斤拷臍 锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟絕锟阶獲锟斤拷知锟斤拷同锟斤拷锟节欙拷锟斤拷锟斤拷锟斤拷茫锟斤拷艿锟斤拷R锟斤拷锟紻锟斤拷锟斤拷锟矫碉拷锟斤拷A[26]锟斤拷
2.4 毛锟斤拷锟絞锟斤拷锟絴锟缴硷拷锟斤拷 毛锟斤拷锟絞锟斤拷锟絴锟缴硷拷锟斤拷锟斤拷hair follicle mesenchyma stem cell, HFMSCs锟斤拷锟街诧拷锟节兩傦拷锟斤拷位锟斤拷毛锟斤拷锟津部碉拷锟斤拷皮锟斤拷 锟絕锟斤拷dermal papilla, DP锟斤拷锟斤拷毛锟斤拷锟斤拷锟斤拷锟斤拷拥锟斤拷锟狡わ拷剩锟絛ermal papilla, DS锟斤拷锟斤拷[1- 2]锟斤拷通锟絕锟斤拷锟斤拷锟皆碉拷锟斤拷 DP 锟斤拷 DS 锟絞锟絯 锟斤拷锟斤拷锟斤拷锟紽(xi锟斤拷n)锟絊毛锟絣(f锟斤拷)锟斤拷锟节碉拷 DP 锟斤拷 DS 锟斤拷锟斤拷锟斤拷锟截組[3- 4]锟斤拷锟斤拷锟斤拷趤锟皆达拷诠锟斤拷锟�锟斤拷脂锟斤拷锟斤拷臍锟斤拷锟饺組锟斤拷锟斤拷锟絞锟斤拷锟絴锟缴硷拷锟斤拷锟斤拷 HFMSCs 锟斤拷锟叫侊拷源锟絊锟斤拷锟斤拷取锟侥猴拷锟斤拷锟斤拷锟斤拷锟紺锟絯锟斤拷(chu锟斤拷ng)锟斤拷小锟揭無锟斤拷锟絞锟斤拷锟狡等冿拷(y锟斤拷u)锟絚锟斤拷HFMSCs 也锟斤拷锟叫成骨★拷锟斤拷脂锟酵筹拷軟锟斤拷 锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷詷锟接涳拷锟斤拷锟� CD44锟斤拷CD73锟斤拷CD90锟斤拷CD105[5- 7]锟斤拷HFMSCs 锟侥凤拷锟絰锟斤拷锟斤拷锟斤拷锟皆碉拷锟斤拷酶 + 锟絲原酶锟斤拷锟斤拷皮脂 锟斤拷锟斤拷 2 mm 锟斤拷锟铰碉拷毛锟斤拷锟铰讹拷锟斤拷锟経锟斤拷锟斤拷锟紹(y锟斤拷ng)锟斤拷通锟絕锟斤拷锟斤拷锟街撅拷锟斤拷锟絰锟斤拷 HFMSCs[8- 9]锟斤拷锟斤拷锟斤拷 HFMSCs 锟斤拷锟絯锟斤拷锟斤拷锟紹(y锟斤拷ng)锟絕锟斤拷 锟斤拷锟斤拷锟絋锟斤拷锟斤拷锟斤拷锟斤拷u锟斤拷失锟斤拷锟斤拷锟斤拷目前锟絇锟节維锟斤拷 HFMSCs 锟缴硷拷锟斤拷锟斤拷锟皆的凤拷锟斤拷锟斤拷要锟斤拷 3D 锟斤拷锟紹(y锟斤拷ng)锟斤拷锟斤拷锟斤拷锟揭滴凤拷锟斤拷ECM 锟斤拷锟斤拷LBL 锟斤拷锟斤拷[9- 12]锟斤拷
2.5 锟斤拷锟斤拷锟絞锟斤拷锟絴锟缴硷拷锟斤拷 锟斤拷锟斤拷锟絞锟斤拷锟絴锟缴硷拷锟斤拷锟斤拷human dental pulp stem cells, hDPSCs锟斤拷锟斤拷锟斤拷锟斤拷锟絯锟斤拷锟斤拷M锟斤拷锟叫达拷锟节碉拷一锟絅锟絞锟斤拷锟絴锟缴硷拷锟斤拷锟斤拷锟絚锟斤拷锟斤拷锟絞锟斤拷锟絴锟缴硷拷锟斤拷一锟接撅拷锟叫很忥拷锟斤拷锟斤拷殖锟斤拷锟斤拷锟斤拷锟揭革拷锟铰和讹拷锟斤拷只锟斤拷锟斤拷锟�,同锟絩還锟斤拷锟斤拷锟斤拷锟斤拷锟絳锟斤拷(ji锟斤拷)锟斤拷锟杰和濓拷 锟节的組锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷[27- 28]锟斤拷hDPSCs 锟絚 BMMSCs 锟斤拷锟斤拷锟斤拷锟狡碉拷锟斤拷锟竭憋拷锟酵ｏ拷同锟接憋拷锟絖 CD73锟斤拷CD90 锟斤拷 CD105锟斤拷锟斤拷锟斤拷锟絖 CD14锟斤拷CD34 锟斤拷 CD45 锟饺憋拷锟斤拷锟接�锟斤拷锟斤拷 hDPSCs 锟斤拷锟叫革拷锟竭碉拷锟斤拷殖锟绞和匡拷隆锟轿筹拷锟斤拷锟斤拷[27]锟斤拷锟斤拷锟斤拷锟街�锟斤拷锟窖凤拷锟絰锟斤拷锟絙 锟斤拷锟斤拷 8 锟絅锟斤拷同锟斤拷 hDPSCs锟斤拷锟斤拷锟叫戯拷锟斤拷锟斤拷锟絍锟斤拷锟斤拷锟斤拷 hDFSCs锟斤拷锟斤拷锟斤拷x锟斤拷锟紹(y锟斤拷ng)锟侥凤拷锟斤拷锟絚锟斤拷锟斤拷锟組锟斤拷锟絞锟斤拷锟絴锟缴硷拷锟斤拷锟斤拷锟斤拷 锟斤拷锟絒29]锟斤拷
2.6 锟斤拷胎锟缴硷拷锟斤拷锟斤拷锟絋锟斤拷锟皆多功锟杰干硷拷锟斤拷锟斤拷锟斤拷锟斤拷锟缴硷拷锟斤拷 锟斤拷胎锟缴硷拷锟斤拷锟斤拷embryonic stem cells, ESCs锟斤拷锟斤拷一锟絅锟斤拷锟斤拷锟斤拷锟斤拷胎锟斤拷燃锟斤拷锟斤拷F锟叫凤拷锟絰锟斤拷锟斤拷锟斤拷全锟杰干硷拷锟斤拷锟斤拷锟斤拷锟斤拷 锟斤拷 3 锟斤拷锟竭層分伙拷锟斤拷锟斤拷锟絯锟饺伙拷锟絯锟斤拷h(hu锟斤拷n)锟斤拷锟斤拷锟缴憋拷锟絋锟斤拷锟街伙拷锟斤拷C锟絯锟阶猴拷锟斤拷锟叫硷拷锟斤拷锟斤拷锟絒30]锟斤拷ESCs 锟斤拷锟絖锟斤拷锟截拷锟皆橈拷志 锟斤拷锟斤拷锟� SSEA- 3锟斤拷SSEA- 4锟斤拷TRA- 1- 60锟斤拷TRA- 1- 81锟斤拷TRA- 2- 49/6E 锟斤拷 Nanog[31]锟斤拷然锟斤拷锟斤拷胎锟缴硷拷锟斤拷锟斤拷使锟斤拷锟皆达拷锟斤拷锟絃 锟経锟酵傦拷锟巾問锟絵锟斤拷锟絋锟斤拷锟皆多功锟杰干硷拷锟斤拷锟斤拷induced pluripotent stem cells锟斤拷iPSCs锟斤拷锟斤拷锟斤拷锟矫诧拷锟斤拷锟斤拷锟侥筹拷锟絯锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷 锟斤拷锟紻锟斤拷 Oct4锟斤拷Sox2锟斤拷c- Myc锟斤拷Klf4 锟侥種锟紻锟斤拷锟斤拷樱锟绞癸拷锟斤拷w锟斤拷锟斤拷锟斤拷(zh锟斤拷)锟斤拷去锟街伙拷途锟斤拷锟斤拷锟轿筹拷锟斤拷锟斤拷锟斤拷锟教ワ拷杉锟斤拷锟斤拷亩锟斤拷锟� 锟缴硷拷锟斤拷[32]锟斤拷iPSCs 锟絚 ESCs 锟斤拷锟斤拷锟斤拷锟狡碉拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷論锟较匡拷锟皆分伙拷锟斤拷锟斤拷锟叫筹拷锟絯锟斤拷锟斤拷锟斤拷锟組锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷志锟斤拷锟絚未锟斤拷 锟斤拷锟斤拷 ESCs 锟斤拷啤锟斤拷锟斤拷 ESCs锟斤拷iPSCs 锟斤拷锟絉锟侥傦拷锟斤拷锟斤拷锟铰狅拷锟絟锟絕小锟斤拷锟斤拷 iPSCs 锟絋锟斤拷锟斤拷锟絞锟斤拷锟絉锟斤拷锟絋锟斤拷效锟绞碉拷锟斤拷锟斤拷锟斤拷锟斤拷 锟斤拷锟斤拷锟斤拷锟絃锟斤拷锟絒锟斤拷锟絃锟経锟斤拷锟斤拷锟斤拷(zh锟斤拷n)[33- 34]锟斤拷锟斤拷锟斤拷锟侥干硷拷锟斤拷還锟斤拷锟斤拷胎锟絇锟斤拷锟斤拷水锟皆硷拷锟斤拷液锟饺侊拷源锟絞锟斤拷锟絴锟缴硷拷锟斤拷锟斤拷锟紷些锟斤拷锟斤拷 也锟斤拷锟叫讹拷锟斤拷只锟斤拷锟斤拷锟斤拷锟斤拷^锟竭碉拷锟斤拷殖锟斤拷锟斤拷锟斤拷
3 锟缴硷拷锟斤拷锟斤拷锟斤拷锟揭�(gu锟斤拷)锟斤拷
锟斤拷锟絴锟斤拷锟斤拷(w锟斤拷n)锟斤拷锟斤拷锟斤拷杉锟斤拷锟斤拷Y源锟角干硷拷锟斤拷锟斤拷锟斤拷锟叫碉拷锟絇锟絀锟絟(hu锟斤拷n)锟斤拷(ji锟斤拷)锟斤拷锟酵滐拷锟斤拷锟斤拷锟斤拷婕硷拷g锟斤拷杉锟斤拷锟斤拷锟斤拷\輸锟斤拷锟絃锟节达拷 锟斤拷锟斤拷锟斤拷锟皆和癸拷锟杰的憋拷锟斤拷锟结供锟斤拷锟斤拷锟絇锟斤拷要锟侥憋拷锟紺锟斤拷锟叫撅拷锟斤拷锟斤拷锟組锟斤拷锟酵硷拷锟斤拷锟絤然锟斤拷锟斤拷锟斤拷 - 196 锟斤拷蜏锟斤拷锟斤拷L锟节憋拷锟斤拷锟斤拷 锟斤拷锟絪锟斤拷锟节斤拷锟截和復滐拷锟絕锟斤拷锟斤拷锟斤拷锟斤拷液锟斤拷锟結锟斤拷锟节伙拷锟皆硷拷锟斤拷液锟紹透锟斤拷變锟斤拷锟斤拷锟斤拷锟截碉拷锟斤拷锟矫讹拷锟絣(f锟斤拷)锟斤拷锟絧锟斤拷[35]锟斤拷锟斤拷锟斤拷p锟斤拷通 锟斤拷原锟斤拷锟斤拷锟斤拷 - 60~0 锟芥細锟斤拷锟饺憋拷锟斤拷锟轿成ｏ拷锟节岋拷锟斤拷锟斤拷锟斤拷锟街憋拷訐p锟斤拷锟斤拷同锟絩锟斤拷锟铰硷拷锟斤拷锟斤拷锟斤拷锟斤拷A锟饺★拷锟紹透锟斤拷锟饺發(f锟斤拷)锟斤拷锟斤拷變锟斤拷通锟絕锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷o锟斤拷锟酵筹拷锟斤拷锟皆斤拷锟截ｏ拷锟缴減锟劫硷拷锟斤拷锟饺憋拷锟斤拷锟轿筹拷锟斤拷锟斤拷呒锟斤拷锟斤拷锟斤拷浴锟斤拷锟斤拷锟斤拷锟給锟斤拷锟斤拷锟斤拷(j锟斤拷)锟斤拷锟角凤拷 透锟斤拷锟斤拷膜通锟斤拷锟街烇拷纱锟斤拷锟斤拷锟斤拷锟斤拷锟紹透锟斤拷锟斤拷锟斤拷锟斤拷o锟斤拷锟酵非滲透锟斤拷锟斤拷锟斤拷锟斤拷o锟斤拷[35]锟斤拷锟紹透锟斤拷锟斤拷锟斤拷锟斤拷o锟斤拷锟斤拷锟斤拷小锟斤拷锟斤拷 锟斤拷锟斤拷锟斤拷锟絴锟斤拷锟斤拷锟斤拷锟矫烇拷锟斤拷锟斤拷水锟結锟斤拷锟絕锟斤拷锟斤拷锟絧锟劫岋拷锟斤拷锟斤拷锟結锟斤拷锟酵癸拷锟杰碉拷锟狡夛拷锟斤拷锟斤拷要锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟阶伙拷锟斤拷锟斤拷锟斤拷DMSO锟斤拷锟斤拷 锟斤拷锟斤拷锟斤拷锟斤拷锟揭讹拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟阶达拷锟斤拷锟斤拷锟角滲透锟皆憋拷锟給锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟絴锟斤拷通锟絕锟斤拷锟斤拷锟斤拷锟絴锟斤拷葋锟絧锟劫低溫冿拷锟芥對锟斤拷 锟斤拷锟侥損锟斤拷锟斤拷锟斤拷要锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟揭讹拷锟斤拷锟斤拷锟絬锟揭伙拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷烯锟斤拷锟斤拷锟斤拷酮锟斤拷锟较撅拷锟斤拷锟斤拷锟阶碉拷锟阶碉拷锟斤拷锟斤拷同锟絅锟缴硷拷锟斤拷锟侥碉拷 锟斤拷锟斤拷锟斤拷锟斤拷锟皆诧拷锟斤拷同, 锟斤拷锟斤拷锟斤拷锟斤拷p锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟叫诧拷同锟斤拷锟斤拷锟�锟斤拷锟斤拷锟斤拷锟斤拷锟叫碉拷锟斤拷训蜏乇锟斤拷娣斤拷锟斤拷锟斤拷娌煌拷母杉锟� 锟斤拷锟斤拷锟杰確锟斤拷锟酵溫猴拷母杉锟斤拷锟�“锟斤拷全 - 锟斤拷效”[36- 38]锟斤拷
4 锟斤拷锟斤拷锟睫忥拷锟斤拷锟斤拷锟絀锟斤拷杉锟斤拷锟斤拷锟斤拷锟揭拷R锟斤拷锟叫撅拷锟斤拷锟斤拷
4.1 锟斤拷锟斤拷锟接組锟斤拷血锟杰伙拷锟酵匡拷锟絯锟絊锟斤拷锟叫的戯拷锟斤拷 锟組锟斤拷血锟絓锟较礙锟斤拷锟斤拷锟斤拷锟斤拷瞥锟教庯拷锟斤拷膯锟斤拷}锟斤拷锟缴硷拷锟斤拷锟缴憋拷锟斤拷锟斤拷锟轿拷皮锟斤拷缺血锟斤拷锟斤拷锟斤拷锟組锟斤拷缺血锟皆硷拷锟斤拷锟斤拷锟絉锟斤拷 前锟叫撅拷锟斤拷锟紺锟斤拷锟斤拷锟缴硷拷锟斤拷锟叫达拷锟組锟斤拷锟斤拷锟絯锟狡★拷锟缴管碉拷锟斤拷锟斤拷锟斤拷锟缴革拷锟斤拷皮锟斤拷血液循锟絟(hu锟斤拷n)锟斤拷锟斤拷锟組皮锟斤拷苫锟絒39- 40]锟斤拷锟斤拷缺血锟斤拷锟斤拷 锟斤拷锟斤拷植皮锟斤拷燃锟斤拷車锟斤拷M锟斤拷锟斤拷注锟斤拷 SVF锟斤拷锟斤拷锟絕锟届到皮锟斤拷血锟絓锟斤拷锟斤拷锟紷锟斤拷锟狡ｏ拷锟街癸拷锟杰革拷锟斤拷[41]锟斤拷锟缴硷拷锟斤拷锟斤拷锟斤拷肢缺血锟斤拷锟斤拷 锟斤拷也锟叫戯拷锟斤拷锟斤拷锟节囷拷锟斤拷锟斤拷肢缺血锟侥诧拷锟斤拷锟叫ｏ拷通锟絕锟斤拷锟斤拷锟阶拷锟� CD133+ 锟侥干硷拷锟斤拷锟斤拷锟缴刺硷拷锟斤拷血锟斤拷锟斤拷锟斤拷[42- 43]锟斤拷锟斤拷锟斤拷锟斤拷 锟斤拷锟斤拷锟斤拷锟斤拷BMMSCs 锟斤拷锟斤拷锟斤拷锟紸锟斤拷锟绞猴拷锟斤拷锟桔伙拷锟斤拷锟斤拷植锟斤拷皮锟絯锟斤拷植锟斤拷锟斤拷湛s[13]锟斤拷锟斤拷锟斤拷锟斤拷皮锟铰局诧拷锟斤拷锟斤拷 BMMSCs 锟斤拷锟斤拷 锟紷锟斤拷锟斤拷锟叫★拷锟截讹拷萎锟絪锟斤拷锟筋瘡锟斤拷锟斤拷锟揭無锟斤拷锟紷锟斤拷锟斤拷锟斤拷[14]锟斤拷還锟斤拷锟叫撅拷锟斤拷锟斤拷 ADSCs 锟轿拷系锟統(t锟斤拷ng)锟斤拷硬锟斤拷锟結锟斤拷指锟剿濓拷锟斤拷锟斤拷 锟絣(f锟斤拷)锟紽(xi锟斤拷n)锟缴达拷锟組锟斤拷(chu锟斤拷ng)锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷痛锟結锟斤拷锟斤拷止锟斤拷锟絒44]锟斤拷
4.2 锟节勶拷(chu锟斤拷ng)锟斤拷锟斤拷皮锟絯锟斤拷锟斤拷锟絚锟斤拷(chu锟斤拷ng)锟斤拷锟斤拷锟斤拷锟叫的戯拷锟斤拷 锟斤拷(chu锟斤拷ng)锟斤拷锟接硷拷锟斤拷锟絍锟斤拷位锟斤拷锟斤拷锟斤拷皮锟絯缺锟絧锟斤拷锟斤拷l(f锟斤拷)锟斤拷同锟絩锟斤拷锟斤拷锟斤拷锟斤拷锟絵锟杰硷拷锟斤拷锟斤拷锟斤拷锟絣(f锟斤拷)锟斤拷皮锟絯锟斤拷锟斤拷锟斤拷(chu锟斤拷ng)锟斤拷也锟角高發(f锟斤拷) 锟斤拷[45]锟斤拷锟斤拷锟斤拷锟斤拷l(f锟斤拷)锟紽(xi锟斤拷n)锟缴硷拷锟斤拷锟斤拷通锟絕直锟接分伙拷锟斤拷锟皆凤拷锟斤拷锟斤拷锟絃锟斤拷锟接等讹拷锟斤拷途锟斤拷锟斤拷锟絚皮锟絯锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷碌募锟斤拷锟狡� 锟絯全锟斤拷缺锟絧锟斤拷锟斤拷锟街诧拷注锟斤拷 ADSCs 锟缴縮锟教勶拷(chu锟斤拷ng)锟斤拷锟斤拷锟较時锟絞锟斤拷锟絧锟斤拷锟絕锟絣(f锟斤拷)锟斤拷锟桔旓拷锟絪锟斤拷色锟截筹拷锟斤拷锟斤拷锟斤拷锟斤拷锟侥發(f锟斤拷)锟斤拷[46]锟斤拷锟斤拷锟斤拷 锟斤拷锟斤拷锟斤拷锟斤拷锟皆勶拷(chu锟斤拷ng)锟斤拷榷锟絅锟統锟斤拷锟皆勶拷(chu锟斤拷ng)锟斤拷锟斤拷委锟斤拷校锟斤拷趧锟�(chu锟斤拷ng)锟斤拷邊锟斤拷锟斤拷锟斤拷锟斤拷注锟斤拷杉锟斤拷锟斤拷锟斤拷锟叫э拷锟斤拷M锟組锟斤拷血锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷 锟斤拷芽锟組锟斤拷锟轿成★拷锟斤拷锟狡組锟斤拷血锟斤拷锟斤拷同锟絩锟斤拷锟組锟斤拷(chu锟斤拷ng)锟斤拷锟斤拷锟絴锟轿成硷拷锟斤拷锟斤拷锟斤拷殖锟斤拷锟斤拷锟劫勶拷(chu锟斤拷ng)锟斤拷锟斤拷锟斤拷皮锟斤拷锟組锟斤拷锟斤拷锟組锟斤拷锟斤拷[47- 48]锟斤拷锟斤拷锟絕 锟节無毛锟揭碉拷皮片锟斤拷锟斤拷锟斤拷毛锟絣(f锟斤拷)锟斤拷皮锟絯锟斤拷植锟斤拷锟斤拷锟斤拷毛锟揭干硷拷锟斤拷锟酵革拷锟斤拷谋锟狡わ拷杉锟斤拷锟�锟斤拷锟节达拷锟組锟斤拷锟皆濓拷锟斤拷锟斤拷锟斤拷锟叫匡拷 锟絖锟斤拷锟斤拷锟矫碉拷效锟斤拷[49]锟斤拷皮锟絯锟経锟斤拷锟斤拷锟斤拷锟街诧拷锟侥忥拷锟斤拷锟斤拷锟絋锟斤拷血液循锟絟(hu锟斤拷n)锟叫干硷拷锟斤拷锟斤拷U锟斤拷皮锟絯锟街诧拷锟絯锟斤拷锟斤拷锟节局诧拷锟斤拷植锟斤拷通锟絕锟街伙拷锟酵合筹拷锟斤拷锟絃锟斤拷锟接达拷锟組锟経锟斤拷皮锟絯锟組锟斤拷锟斤拷锟斤拷[50]锟斤拷锟斤拷锟斤拷锟叫撅拷锟紺锟斤拷锟斤拷锟缴硷拷锟斤拷锟节达拷锟組锟斤拷锟较伙拷锟斤拷衰锟较猴拷锟狡わ拷w锟斤拷 锟斤拷锟斤拷锟絧锟斤拷锟饺凤拷锟斤拷锟斤拷锟紷锟斤拷效锟斤拷[51]锟斤拷
4.3 锟斤拷脂锟斤拷锟斤拷植锟斤拷锟斤拷锟斤拷锟叫的戯拷锟斤拷 脂锟斤拷锟斤拷植锟斤拷軟锟組锟斤拷萎锟絪锟斤拷缺锟絧锟睫復碉拷锟斤拷要锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷植锟斤拷脂锟斤拷锟組锟斤拷锟斤拷锟斤拷缺锟斤拷血锟斤拷锟絚锟斤拷锟絃锟斤拷锟接ｏ拷锟斤拷锟斤拷锟紽(xi锟斤拷n)锟絕 锟竭碉拷锟斤拷锟斤拷锟绞硷拷锟絯锟絊锟斤拷锟斤拷锟絵锟斤拷锟饺現(xi锟斤拷n)锟斤拷影锟斤拷浏熜52]锟斤拷锟斤拷锟矫干硷拷锟斤拷锟給锟斤拷脂锟斤拷锟斤拷植锟斤拷cell- assisted lipotransfer, CAL锟斤拷 锟斤拷脂锟斤拷锟斤拷锟斤拷锟缴伙拷锟斤拷锟斤拷锟�锟斤拷锟組锟斤拷锟結锟斤拷锟轿態(t锟斤拷i)锟斤拷锟斤拷锟斤拷锟斤拷锟絣(f锟斤拷)锟結锟斤拷锟斤拷[53- 55]锟斤拷锟斤拷锟介房脂锟斤拷锟斤拷锟斤拷锟�锟斤拷锟斤拷锟斤拷杉锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷植 锟斤拷脂锟斤拷锟侥成伙拷锟斤拷锟斤拷锟絧锟斤拷脂锟斤拷注锟斤拷锟斤拷w锟絊锟斤拷锟斤拷锟斤拷锟絒锟饺诧拷锟絣(f锟斤拷)锟結锟侥發(f锟斤拷)锟斤拷锟斤拷锟斤拷同锟絩未锟絕锟届到脂锟斤拷锟斤拷锟斤拷锟斤拷殖锟斤拷锟絒锟斤拷锟饺诧拷锟絣(f锟斤拷) 锟結锟侥發(f锟斤拷)锟斤拷[55- 56]锟斤拷锟斤拷锟解，锟节帮拷锟斤拷萎锟絪锟斤拷锟轿拷锟斤拷锟斤拷也锟絕锟届到锟斤拷锟斤拷 CAL 锟斤拷锟斤拷锟街拷锟斤拷某苫锟斤拷锟絒57]锟斤拷
4.4 锟斤拷毛锟絣(f锟斤拷)锟斤拷锟斤拷锟叫的戯拷锟斤拷 脫锟絣(f锟斤拷)锟斤拷锟斤拷锟絖锟紽(xi锟斤拷n)锟斤拷锟剿碉拷锟斤拷要锟斤拷锟絵锟斤拷锟斤拷锟斤拷锟絚锟桔硷拷锟截达拷锟絰锟斤拷锟斤拷锟紾酮锟斤拷锟絇锟侥达拷锟絰锟较礙锟斤拷锟絇锟斤拷也锟絚毛锟斤拷锟杰囷拷血锟斤拷 锟斤拷锟絧锟劫猴拷锟斤拷锟絃锟斤拷锟斤拷失去平锟斤拷锟斤拷锟絇[58]锟斤拷锟缴硷拷锟斤拷锟斤拷锟节碉拷血锟杰冿拷皮锟斤拷锟絃锟斤拷锟接★拷锟轿硷拷锟斤拷锟斤拷锟絃锟斤拷锟斤拷锟斤拷锟饺島锟截橈拷锟斤拷锟絃锟斤拷锟斤拷锟斤拷 血小锟斤拷锟斤拷锟斤拷锟斤拷锟絃锟斤拷锟接等讹拷N锟斤拷锟斤拷锟斤拷锟斤拷[59]锟斤拷一锟斤拷锟斤拷锟斤拷{锟截忥拷锟絪锟斤拷毛锟絣(f锟斤拷)锟斤拷锟絃锟斤拷锟斤拷锟斤拷锟斤拷一锟斤拷锟斤拷纱锟斤拷M毛锟斤拷锟杰囷拷锟斤拷血 锟杰伙拷[60]锟斤拷锟絋锟斤拷毛锟斤拷锟斤拷皮锟斤拷锟絕锟斤拷殖锟斤拷锟絳锟斤拷毛锟斤拷锟斤拷锟斤拷止锟斤拷锟組锟斤拷锟斤拷锟絃锟斤拷锟斤拷锟斤拷锟組毛锟絣(f锟斤拷)锟斤拷锟絃锟斤拷锟矫拷l(f锟斤拷)锟斤拷锟斤拷K毛[61- 62]锟斤拷锟斤拷脫 锟絣(f锟斤拷)锟絕(q锟斤拷)锟斤拷皮锟絯锟斤拷注锟斤拷 ADSCs 锟斤拷 SVF锟斤拷锟斤拷锟絕锟届到注锟斤拷^(q锟斤拷)锟斤拷毛锟絣(f锟斤拷)锟杰讹拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷毛锟絣(f锟斤拷)直锟斤拷锟紷锟斤拷锟斤拷锟斤拷[63- 64]锟斤拷ADSCs 锟斤拷 锟絣锟斤拷锟斤拷锟紹(y锟斤拷ng)锟斤拷也锟斤拷锟叫达拷锟組毛锟絣(f锟斤拷)锟斤拷锟斤拷锟斤拷效锟斤拷锟斤拷锟斤拷锟阶拷锟斤拷效锟斤拷锟絚锟斤拷锟斤拷锟桔帮拷锟斤拷效锟接斤拷[65]锟斤拷锟斤拷锟絯 BMMSCs 锟斤拷锟斤拷锟絯 HFMSCs 也锟斤拷锟斤拷锟斤拷锟斤拷委锟斤拷y锟斤拷锟皆帮拷片锟斤拷脫锟絣(f锟斤拷)锟斤拷锟桔硷拷锟斤拷锟斤拷脫锟絣(f锟斤拷)锟斤拷锟斤拷锟紷锟斤拷锟斤拷锟斤拷[66]锟斤拷
4.5 锟节癸拷锟絚軟锟斤拷锟斤拷锟斤拷锟叫的戯拷锟斤拷 目前針岋拷锟斤拷(chu锟斤拷ng)锟斤拷锟斤拷锟絒锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷蔚葘锟斤拷碌墓呛锟杰涳拷锟饺憋拷p锟斤拷锟睫忥拷锟斤拷锟絉锟斤拷锟斤拷锟斤拷要锟斤拷锟矫碉拷锟斤拷锟斤拷锟絯锟組锟斤拷锟斤拷植锟斤拷锟斤拷 锟絯锟組锟斤拷锟斤拷植锟斤拷锟斤拷锟斤拷锟街诧拷锟饺凤拷锟斤拷锟斤拷锟斤拷锟斤拷锟矫凤拷锟斤拷锟斤拷锟轿拷效锟斤拷锟斤拷一锟斤拷锟侥撅拷锟斤拷锟斤拷[67- 69]锟斤拷BMMSCs 锟斤拷 ADSCs 锟斤拷锟节骨猴拷 軟锟斤拷缺锟絧锟絉锟斤拷锟叫撅拷锟斤拷锟斤拷锟斤拷锟筋常見锟侥干硷拷锟斤拷锟斤拷锟�锟斤拷锟斤拷锟�锟斤拷軟锟角的局诧拷缺锟絧注锟斤拷 BMMSCs 锟斤拷 ADSCs 锟缴达拷锟組锟組锟斤拷 锟睫忥拷锟斤拷锟斤拷[70- 72]锟斤拷锟斤拷锟缴硷拷锟斤拷锟絚锟斤拷锟斤拷支锟杰诧拷锟较復猴拷锟斤拷锟斤拷锟紿锟斤拷锟斤拷吒杉锟斤拷锟斤拷锟斤拷锟叫э拷锟�锟斤拷锟斤拷锟斤拷支锟杰诧拷锟较碉拷锟斤拷锟斤拷也锟斤拷杉锟� 锟斤拷锟斤拷锟斤拷锟结供锟斤拷锟斤拷锟斤拷锟斤拷微锟絟(hu锟斤拷n)锟斤拷锟斤拷使锟斤拷锟斤拷懈锟斤拷锟�(w锟斤拷n)锟斤拷锟侥結锟斤拷锟酵革拷锟斤拷(y锟斤拷u)锟斤拷锟侥癸拷锟斤拷[73]锟斤拷锟絇锟斤拷(ji锟斤拷)腔锟斤拷注锟斤拷 ADSCs锟斤拷BMMSCs 锟斤拷 hDPSCs锟斤拷锟斤拷锟斤拷通锟絕锟絳锟斤拷(ji锟斤拷)锟街诧拷锟阶癥锟斤拷锟斤拷锟組軟锟斤拷锟斤拷锟斤拷锟睫復從讹拷锟斤拷锟斤拷锟斤拷痛锟斤拷锟斤拷锟斤拷锟絇锟斤拷(ji锟斤拷)锟阶的發(f锟斤拷)展[74]锟斤拷锟絉锟斤拷锟叫撅拷锟紷示锟斤拷锟斤拷 锟斤拷锟絯锟缴硷拷锟斤拷锟轿拷锟斤拷缺锟絧锟角帮拷全锟斤拷效锟斤拷锟斤拷锟叫無锟叫撅拷锟紷示锟絣(f锟斤拷)锟斤拷锟阶癥锟斤拷锟斤拷染锟斤拷锟組锟斤拷锟絕锟斤拷锟斤拷锟絃锟斤拷锟絒锟斤拷锟絣(f锟斤拷)锟斤拷锟斤拷[75]锟斤拷
5 锟缴硷拷锟斤拷锟斤拷锟斤拷锟斤拷膽锟斤拷锟斤拷芯锟�
锟缴硷拷锟斤拷锟斤拷锟劫產品锟斤拷锟斤拷锟缴硷拷锟斤拷锟絣锟斤拷锟斤拷锟紹(y锟斤拷ng)液锟斤拷conditioned medium, CM锟斤拷锟斤拷锟斤拷锟組锟組锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟絃锟斤拷锟接ｏ拷growth factor, GF锟斤拷锟斤拷锟斤拷锟絰锟斤拷血液锟侥革拷血小锟斤拷血锟絳锟斤拷platelet rich plasma, PRP锟斤拷锟斤拷[76- 78]锟斤拷锟斤拷類產品锟斤拷要锟斤拷锟斤拷效锟缴凤拷锟角干硷拷锟斤拷 锟斤拷锟节碉拷锟斤拷锟絃锟斤拷锟接ｏ拷使锟矫凤拷锟斤拷锟斤拷锟斤拷锟斤拷锟絲锟斤拷锟狡勶拷涂抹锟斤拷(chu锟斤拷ng)锟斤拷锟斤拷锟街诧拷锟組锟斤拷锟斤拷注锟斤拷锟斤拷锟斤拷约锟揭猴拷w锟絘品锟节局诧拷锟組锟斤拷锟饺碉拷注 锟戒。通锟絕锟斤拷锟较伙拷锟斤拷皮锟絯锟斤拷锟絘锟斤拷锟斤拷锟絃锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟狡わ拷w通锟絕锟斤拷锟絅锟斤拷锟斤拷锟斤拷锟接达拷锟組锟斤拷皮锟接冿拷锟絯锟絊母锟斤拷锟斤拷锟斤拷锟斤拷殖锟斤拷锟斤拷锟斤拷 锟睫忥拷锟较伙拷锟斤拷锟絲原锟絯锟絊锟絚锟斤拷锟斤拷锟絯锟絊锟斤拷還原锟斤拷锟絯锟斤拷锟皆诧拷锟絧锟劫帮拷锟統锟斤拷锟斤拷脫锟絣(f锟斤拷)锟轿拷锟叫局诧拷注锟斤拷锟筋惍a品锟缴达拷锟組毛锟斤拷 锟侥活化锟斤拷锟斤拷锟斤拷锟斤拷PRP 類產品一锟斤拷锟斤拷锟斤拷R锟斤拷锟紺锟斤拷直锟接采硷拷锟紷锟�锟�锟斤拷CM锟斤拷 GF 類產品锟絫锟斤拷要锟缴凤拷锟斤拷 GMP 锟剿準的岋拷 锟絀(y锟斤拷)锟缴硷拷锟斤拷锟狡勶拷锟斤拷锟絘锟紺锟斤拷锟斤拷锟斤拷藥锟紺锟斤拷锟組锟斤拷锟狡傦拷锟斤拷锟缴硷拷锟斤拷锟斤拷锟斤拷一锟斤拷锟揭拷锟斤拷锟斤拷锟斤拷a品锟斤拷锟斤拷锟絯锟斤拷exosome锟斤拷锟斤拷锟斤拷锟斤拷玫锟� 锟剿廣锟斤拷锟絇注锟斤拷锟斤拷锟斤拷锟絯锟角機锟絯锟饺硷拷锟斤拷通锟絕锟斤拷锟斤拷锟斤拷锟斤拷锟轿成讹拷锟斤拷小锟絯锟斤拷锟斤拷通锟絕锟斤拷锟斤拷膜锟节合凤拷锟节碉拷锟斤拷锟斤拷锟斤拷h(hu锟斤拷n)锟斤拷锟叫碉拷微 小锟斤拷锟斤拷锟斤拷直锟斤拷锟斤拷 30~100 nm[79]锟斤拷锟斤拷群锟斤拷泄锟斤拷锟斤拷缘锟斤拷锟斤拷|锟斤拷mRNA 锟斤拷 microRNA 锟斤拷锟斤拷锟絴锟斤拷锟节硷拷锟斤拷锟絞锟斤拷锟斤拷息锟斤拷锟絝锟絕锟斤拷 锟叫發(f锟斤拷)锟絔锟斤拷要锟斤拷锟斤拷[80]锟斤拷锟斤拷锟斤拷锟絯锟缴從讹拷N锟絯液锟酵硷拷锟斤拷锟斤拷锟紹(y锟斤拷ng)锟斤拷锟斤拷液锟叫凤拷锟絰锟斤拷锟斤拷V锟斤拷使锟矫的凤拷锟絰锟斤拷锟斤拷锟角革拷锟斤拷锟絰锟斤拷锟絚锟斤拷锟絍 锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷l(f锟斤拷)锟紽(xi锟斤拷n) ADSCs- exo锟斤拷锟斤拷锟絚 ADSCs 锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷缘锟斤拷锟斤拷L锟斤拷锟斤拷锟斤拷趨锟斤拷锟斤拷锟斤拷锟斤拷脂锟絴锟饺讹拷N锟斤拷锟斤拷锟斤拷锟絴[81- 82]锟斤拷锟斤拷 锟斤拷锟組血锟杰冿拷皮锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷血小锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟絃锟斤拷锟接可达拷锟組 ADSCs 釋凤拷锟斤拷锟斤拷血锟斤拷锟斤拷锟絃锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟絯[83]锟斤拷锟节癸拷缺 锟絧模锟斤拷锟叫撅拷锟叫發(f锟斤拷)锟紽(xi锟斤拷n)锟斤拷锟斤拷锟斤拷锟斤拷锟絯锟斤拷锟絛锟斤拷锟斤拷锟斤拷支锟斤拷锟斤拷锟斤拷锟叫达拷锟組锟斤拷锟斤拷锟絯锟斤拷锟絚锟絯锟斤拷锟斤拷锟絋锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷[84]锟斤拷锟缴硷拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟絕锟缴硷拷锟斤拷锟絘品锟斤拷锟斤拷锟斤拷锟铰冿拷(y锟斤拷u)锟捷ｏ拷锟斤拷锟节無锟斤拷锟斤拷锟斤拷锟斤拷锟轿拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟阶斤拷锟斤拷锟斤拷同锟絩锟斤拷锟絴锟斤拷锟斤拷(w锟斤拷n)锟斤拷锟斤拷 锟斤拷锟节憋拷锟斤拷锟斤拷锟斤拷锟节癸拷锟斤拷锟斤拷锟絓輸锟斤拷锟斤拷锟斤拷W锟斤拷锟杰诧拷锟絊锟絩锟絞锟斤拷锟絃锟斤拷衰锟絧锟斤拷锟酵匡拷原锟皆ｏ拷同锟絅锟斤拷锟絯锟斤拷锟矫诧拷锟斤拷锟斤拷锟斤拷锟斤拷锟竭凤拷锟斤拷锟斤拷 锟斤拷锟杰曪拷锟饺干硷拷锟斤拷锟絉锟斤拷锟紻锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷R锟斤拷锟斤拷
6 锟斤拷锟結锟絚展锟斤拷
锟缴硷拷锟斤拷锟斤拷锟斤拷锟絯锟斤拷一锟絅锟斤拷锟叫讹拷锟斤拷只锟斤拷锟斤拷锟斤拷头锟斤拷锟斤拷锟斤拷锟斤拷募锟斤拷锟�锟斤拷锟斤拷锟斤拷锟斤拷殖锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟酵碉拷锟斤拷锟絚锟斤拷锟缴硷拷锟斤拷 锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷委锟斤拷蔷锟斤拷锟斤拷锟揭拷R锟斤拷锟斤拷锟斤拷前锟斤拷锟斤拷锟斤拷锟斤拷锟絫(y锟斤拷)锟絎锟街段★拷锟斤拷锟斤拷锟斤拷锟睫忥拷锟斤拷锟斤拷锟斤拷锟斤拷I锟斤拷锟絕锟剿讹拷锟斤拷幕锟斤拷A锟絚锟絉锟斤拷锟叫撅拷锟紺锟斤拷锟斤拷锟节达拷锟組皮锟絯锟斤拷锟斤拷锟絚锟睫忥拷锟斤拷锟組锟斤拷血锟杰伙拷锟斤拷軟锟組锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟絚軟锟斤拷锟睫復★拷锟斤拷M锟斤拷锟斤拷锟絧锟斤拷锟斤拷毛锟斤拷锟斤拷 锟斤拷锟饺多方锟斤拷锟斤拷锟斤拷^锟矫碉拷锟轿拷效锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟借看锟斤拷锟缴硷拷锟斤拷锟斤拷锟斤拷锟叫达拷锟节碉拷锟斤拷突變锟斤拷锟斤拷锟斤拷锟饺嗭拷锟絵锟斤拷未锟斤拷全锟斤拷Q锟斤拷锟斤拷 锟斤拷锟斤拷锟轿拷锟侥標準伙拷锟斤拷锟絵未锟斤拷Q锟斤拷锟絝锟斤拷锟缴硷拷锟斤拷锟斤拷锟轿拷锟斤拷锟斤拷锟叫碉拷锟斤拷锟矫機锟斤拷锟斤拷锟斤拷锟矫凤拷锟斤拷锟斤拷锟斤拷全锟皆猴拷锟斤拷效锟皆等伙拷锟紸锟斤拷 锟絉锟斤拷锟叫撅拷锟斤拷锟斤拷锟組一锟斤拷锟斤拷锟狡★拷
全锟斤拷锟絅锟桔凤拷锟秸熱線锟斤拷400-100-1649 
